MorphoGel
Previous work has shown that the synthetic polymer poloxamer forms a low immunogenicity, but mechanically
strong scaffold that can be used to construct artificial skin. However, its bioactivity is relatively low
due to its nonionic nature. To overcome this limitation, we developed a hybrid hydrogel, known as MorphoGel,
and showed it supports xenogeneic human MSC engraftment in vivo (Hantash, patent pending & Biomaterials, In press).
MorphoGel has numerous uses including serving as a non-immunogenic bioactive extracellular matrix for creation
of Escape's ESC-derived bilayered skin substitute. MorphoGel will also be supplied in research and cGMP grades
for 2-D and 3-D culture of MSCs, ESCs, and other somatic and stem cells used for tissue engineering applications.
MorphoGel features are indicated below:
- Fully defined
- 100% animal-free
- Supports 2-D and 3-D stem cell culture
- Scale up of adherent cells without enzymatic detachment step
- Non-immunogenic cell transplantation vehicle
- Promotes stem cell xenogeneic engraftment
- Maintains multipotency of human MSCs
- Promotes microvascular coagulation
- Research of cGMP grade